Cascading after peridiagnostic cancer genetic testing: an alternative to population-based screening
PURPOSE Despite advances in DNA sequencing technology and expanded medical
guidelines, the vast majority of individuals carrying pathogenic variants of common cancer …
guidelines, the vast majority of individuals carrying pathogenic variants of common cancer …
[HTML][HTML] Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature
L Perez, E Webster, L Bull, JT Brewer, MD Ahsan… - Gynecologic …, 2023 - Elsevier
Objective Increasing evidence suggests the fallopian tube as the site of origin of BRCA1/2-
associated high-grade ovarian cancers. Several ongoing trials are evaluating salpingectomy …
associated high-grade ovarian cancers. Several ongoing trials are evaluating salpingectomy …
When is genomic testing cost-effective? Testing for Lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives
SD Grosse - Healthcare, 2015 - mdpi.com
Varying estimates of the cost-effectiveness of genomic testing applications can reflect
differences in study questions, settings, methods and assumptions. This review compares …
differences in study questions, settings, methods and assumptions. This review compares …
Mismatch repair deficiency testing in patients with colorectal cancer and nonadherence to testing guidelines in young adults
T Shaikh, EA Handorf, JE Meyer, MJ Hall… - JAMA …, 2018 - jamanetwork.com
Importance Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of
sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which …
sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which …
Consequences of universal MSI/IHC in screening ENDOMETRIAL cancer patients for Lynch syndrome
BAL Batte, AS Bruegl, MS Daniels, KL Ring… - Gynecologic …, 2014 - Elsevier
Objective Determine factors impacting the uptake of genetic counseling and results of
genetic testing following universal tumor testing for Lynch syndrome in patients with …
genetic testing following universal tumor testing for Lynch syndrome in patients with …
[HTML][HTML] Comparing universal Lynch syndrome tumor-screening programs to evaluate associations between implementation strategies and patient follow-through
Purpose Universal tumor screening (UTS) for all colorectal cancer patients can improve the
identification of Lynch syndrome, the most common cause of hereditary colorectal cancer …
identification of Lynch syndrome, the most common cause of hereditary colorectal cancer …
Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives
I Salikhanov, K Heinimann, P Chappuis… - Journal of medical …, 2022 - jmg.bmj.com
Background We estimated the cost-effectiveness of universal DNA screening for Lynch
syndrome (LS) among newly diagnosed patients with colorectal cancer (CRC) followed by …
syndrome (LS) among newly diagnosed patients with colorectal cancer (CRC) followed by …
Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine …
Background Systematic screening of all colorectal tumors for Lynch Syndrome (LS) has
been recommended since 2009. Currently, implementation of LS screening in healthcare …
been recommended since 2009. Currently, implementation of LS screening in healthcare …
Cost-effectiveness of routine screening for Lynch syndrome in endometrial cancer patients up to 70 years of age
A Goverde, MCW Spaander, HC van Doorn… - Gynecologic …, 2016 - Elsevier
Purpose To assess cost-effectiveness of routine screening for Lynch Syndrome (LS) in
endometrial cancer (EC) patients≤ 70 years of age. Methods Consecutive EC patients≤ 70 …
endometrial cancer (EC) patients≤ 70 years of age. Methods Consecutive EC patients≤ 70 …
Web-based tool for cancer family history collection: A prospective randomized controlled trial
Objectives Approximately 1% of individuals have a hereditary cancer predisposition
syndrome, however, the majority are not aware. Collecting a cancer family history (CFH) can …
syndrome, however, the majority are not aware. Collecting a cancer family history (CFH) can …