Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain
and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in …

This paper reviews the body of evidence that major depression is accompanied by a
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …

The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …

We investigated oxidative stress in human postmortem frontal cortexfrom individuals
characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n= 4) …

The objective of the present study was to assess the neuroprotective role of rutin (vitamin P)
and delineate the mechanism of action. Recent evidence indicates that rutin exhibits …

Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

The intracerebroventricular (icv) application of streptozotocin (STZ) in low dosage was used
in 3‐month‐old rats to explore brain insulin system dysfunction. Three months following STZ …

Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …

A growing body of evidence implicates impairments in brain insulin signaling in early
sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted …

It is well known that coenzyme Q10 (CoQ10) has important antioxidant properties. Because
one of the main mechanisms involved in the pathogenesis of Alzheimer's disease (AD) and …