TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Metabolic activities in normal cells rely primarily on mitochondrial oxidative phosphorylation
(OXPHOS) to generate ATP for energy. Unlike in normal cells, glycolysis is enhanced and …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Although required for life, paradoxically, mitochondria are often essential for initiating
apoptotic cell death. Mitochondria regulate caspase activation and cell death through an …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Tricine–SDS-PAGE is commonly used to separate proteins in the mass range 1–100 kDa. It
is the preferred electrophoretic system for the resolution of proteins smaller than 30 kDa. The …

Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …