Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive
potential for disease modelling and regenerative medicine. However, the limited …

Recent studies implicated the existence in adult human kidney of a population of renal
progenitors with the potential to regenerate glomerular as well as tubular epithelial cells and …

The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

The loss of glomerular podocytes is a key event in the progression of chronic kidney disease
resulting in proteinuria and declining function. Podocytes are slow cycling cells that are …

Podocyte loss is a major determinant of progressive CKD. Although recent studies showed
that a subset of parietal epithelial cells can serve as podocyte progenitors, the role of …

Glomerular diseases are the leading causes of chronic and end-stage kidney disease. In the
1980s and 1990s, attention was focused on the biology and role of glomerular endothelial …