Nanobodies: natural single-domain antibodies

S Muyldermans - Annual review of biochemistry, 2013 - annualreviews.org
Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …

Assessing developability early in the discovery process for novel biologics

ML Fernández-Quintero, A Ljungars, F Waibl, V Greiff… - MAbs, 2023 - Taylor & Francis
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

Composition of sow colostrum and milk

WL Hurley - The gestating and lactating sow, 2015 - brill.com
Components of milk include proteins, lipids, carbohydrates, minerals, vitamins, and cells.
The contents of these components are affected by a variety of factors, with stage of lactation …

Streptococcus suis vaccines: candidate antigens and progress

M Segura - Expert review of vaccines, 2015 - Taylor & Francis
Streptococcus suis is a major swine pathogen and an emerging zoonotic agent of human
meningitis and streptococcal toxic shock-like syndrome. S. suis is a well-encapsulated …

Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection

V Virdi, A Coddens, S De Buck… - Proceedings of the …, 2013 - National Acad Sciences
Oral feed-based passive immunization can be a promising strategy to prolong maternal
lactogenic immunity against postweaning infections. Enterotoxigenic Escherichia coli …

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

JE Butler, KM Lager, W Golde, KS Faaberg… - Immunologic …, 2014 - Springer
Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that
especially affects neonates within the “critical window” of immunological development …

Fc-mediated functions of porcine IgG subclasses

B Paudyal, W Mwangi, P Rijal, JC Schwartz… - Frontiers in …, 2022 - frontiersin.org
The pig is an important agricultural species and powerful biomedical model. We have
established the pig, a large natural host animal for influenza with many physiological …

The piglet as a model for B cell and immune system development

JE Butler, KM Lager, I Splichal, D Francis… - Veterinary immunology …, 2009 - Elsevier
The ability to identify factors responsible for disease in all species depends on the ability to
separate those factors which are environmental from those that are intrinsic. This is …

The evolutionary basis for differences between the immune systems of man, mouse, pig and ruminants

M Bailey, Z Christoforidou, MC Lewis - Veterinary immunology and …, 2013 - Elsevier
Studying the pathogenesis of an infectious disease like colibacillosis requires an
understanding of the responses of target hosts to the organism both as a pathogen and as a …

Progress in the use of swine in developmental immunology of B and T lymphocytes

M Sinkora, JE Butler - Developmental & Comparative Immunology, 2016 - Elsevier
The adaptive immune system of higher vertebrates is believed to have evolved to counter
the ability of pathogens to avoid expulsion because their high rate of germline mutations …