Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

W Finnigan, LJ Hepworth, SL Flitsch, NJ Turner - Nature catalysis, 2021 - nature.com
As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …

[HTML][HTML] Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases

G de Gonzalo, CE Paul - Current Opinion in Green and Sustainable …, 2021 - Elsevier
Alcohol dehydrogenases have fascinated chemists over the span of a few decades to
catalyze oxidation and reduction reactions and have been increasingly incorporated as …

Structural and Biochemical Studies Enlighten the Unspecific Peroxygenase from Hypoxylon sp. EC38 as an Efficient Oxidative Biocatalyst

L Rotilio, A Swoboda, K Ebner, C Rinnofner… - ACS …, 2021 - ACS Publications
Unspecific peroxygenases (UPOs) are glycosylated fungal enzymes that can selectively
oxidize C–H bonds. UPOs employ hydrogen peroxide as the oxygen donor and reductant …

Amine dehydrogenases: Current status and potential value for chiral amine synthesis

J Liu, W Kong, J Bai, Y Li, L Dong, L Zhou, Y Liu, J Gao… - Chem Catalysis, 2022 - cell.com
Chiral amines are crucial precursors of various pharmaceutical drugs, fine chemicals, and
bioactive molecules. Amine dehydrogenases (AmDHs) have attracted increasing attention …

[HTML][HTML] Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases–A bright future for sustainable chemical synthesis

X Xu, T Hilberath, F Hollmann - Current Opinion in Green and Sustainable …, 2023 - Elsevier
Heme-dependent oxygenases (ie P450 monooxygenases and peroxygenases) are highly
selective catalysts for the selective oxyfunctionalisation or organic compounds. Both enzyme …

Recent developments in oxidative biocatalytic cascades

WWL See, JPS Choo, DY Jung, L Zhi - Current Opinion in Green and …, 2022 - Elsevier
Biocatalytic cascades that involve enzymatic oxidation as one or more key steps are
powerful tools to access valuable chemicals with various functionalizations starting from …

Modularization of Immobilized Multienzyme Cascades for Continuous‐Flow Enantioselective C− H Amination

W Kong, C Huang, L Zhou, J Gao, L Ma… - Angewandte Chemie …, 2024 - Wiley Online Library
Multienzyme cascades (MECs) have gained much attention in synthetic chemistry but
remain far from being a reliable synthetic tool. Here we report a four‐enzyme cascade …

Current Status of Amine Dehydrogenases: From Active Site Architecture to Diverse Applications Across a Broad Substrate Spectrum

V Tseliou, MF Masman, T Knaus, FG Mutti - ChemCatChem, 2024 - Wiley Online Library
Amine dehydrogenases (AmDHs) are NAD (P) H‐dependent oxidoreductases that catalyze
the reductive amination between carbonyl compounds and ammonia as the amine donor …

Immobilization of Enzymes on Cyclodextrin-Anchored Dehiscent Mesoporous TiO2 for Efficient Photoenzymatic Hydroxylation

F Jia, Y Liu, X Deng, X Cao, X Zheng… - … Applied Materials & …, 2023 - ACS Publications
A three-in-one heterogeneous catalyst (UPO@ d TiO2-CD) was fabricated by grafting
cyclodextrins (CDs) on the dehiscent TiO2 (d TiO2) surface and subsequently immobilizing …