Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Gene therapy: Comprehensive overview and therapeutic applications

N Sayed, P Allawadhi, A Khurana, V Singh, U Navik… - Life sciences, 2022 - Elsevier
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

Photodynamic therapy in oral cancer: A review of clinical studies

SA Mosaddad, RA Namanloo, SS Aghili, P Maskani… - Medical Oncology, 2023 - Springer
A significant mortality rate is associated with oral cancer, particularly in cases of late-stage
diagnosis. Since the last decades, oral cancer survival rates have only gradually improved …

Antimicrobial photodynamic therapy: Latest developments with a focus on combinatory strategies

R Youf, M Müller, A Balasini, F Thétiot, M Müller… - Pharmaceutics, 2021 - mdpi.com
Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern
therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the …

Recent advances in stimulus‐responsive nanocarriers for gene therapy

C Yu, L Li, P Hu, Y Yang, W Wei, X Deng… - Advanced …, 2021 - Wiley Online Library
Gene therapy provides a promising strategy for curing monogenetic disorders and complex
diseases. However, there are challenges associated with the use of viral delivery vectors …

Conscription of immune cells by light‐activatable silencing NK‐derived exosome (LASNEO) for synergetic tumor eradication

M Zhang, W Shao, T Yang, H Liu, S Guo… - Advanced …, 2022 - Wiley Online Library
Exosomes derived from natural killer (NK) cells (NEO) constitute promising antineoplastic
nano‐biologics because of their versatile functions in immune regulation. However, a …

Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy

Y Sun, Y Sha, G Cui, F Meng, Z Zhong - Advanced Drug Delivery Reviews, 2023 - Elsevier
The development of carrier systems that are able to transport and release therapeutics to
target cells is an emergent strategy to treat cancer; however, they following endocytosis are …

Light-activated siRNA endosomal release (LASER) by porphyrin lipid nanoparticles

Y Mo, MHY Cheng, A D'Elia, K Doran, L Ding, J Chen… - ACS …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have achieved clinical success in delivering small interfering
RNAs (siRNAs) for targeted gene therapy. However, endosomal escape of siRNA into the …

Combinations of photodynamic therapy with other minimally invasive therapeutic technologies against cancer and microbial infections

SP Songca - International Journal of Molecular Sciences, 2023 - mdpi.com
The rapid rise in research and development following the discovery of photodynamic
therapy to establish novel photosensitizers and overcome the limitations of the technology …

[HTML][HTML] Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

J Li, S Wang, F Fontana, C Tapeinos, MA Shahbazi… - Bioactive Materials, 2023 - Elsevier
Remarkable progress in phototherapy has been made in recent decades, due to its non-
invasiveness and instant therapeutic efficacy. In addition, with the rapid development of …