In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These
proteins act as molecular chaperones by assisting proper folding and refolding of misfolded …

Introduction• Main HSPs• HSPs, cell signalling and apoptosis‐HSPs' targets in upstream
signalling pathways‐HSPs' targets at the mitochondrial level‐HSPs' targets at the post …

Although heat shock proteins have been studied for decades, new intracellular and
extracellular functions in a variety of diseases continue to be discovered. Heat shock …

Abstract Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is
induced in response to a wide variety of physiological and environmental insults, including …

Abstract Heat shock protein 70 (Hsp70) is the most ubiquitous stress-inducible chaperone. It
accumulates in the cells in response to a wide variety of physiological and environmental …

The INhibitor of Growth (ING) family of type II tumour suppressors are encoded by five genes
in mammals (ING1–ING5), most of which encode multiple isoforms via splicing, and all of …

The five members of the inhibitor of growth (ING) gene family have garnered significant
interest due to their putative roles as tumor suppressors. However, the precise role (s) of …

We have previously shown that heat shock protein 70 (HSP70) markedly inhibits H 2 O 2-
induced apoptosis in mouse C2C12 myogenic cells by reducing the release of Smac …

Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive
tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA …

Understanding the mechanisms that control stress is central to realize how cells respond to
environmental and physiological insults. All the more important is to reveal how tumour cells …