For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …

Cellular senescence is a biological process by which cells lose their capacity to proliferate
yet remain metabolically active. Although originally considered a protective mechanism to …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty
acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular …

The lung is often overlooked as a metabolically active organ, yet biochemical studies have
long demonstrated that glucose utilization surpasses that of many other organs, including …

Pulmonary surfactant is a crucial and dynamic lung structure whose primary functions are to
reduce alveolar surface tension and facilitate breathing. Though disruptions in surfactant …

Pulmonary fibrosis, a kind of terminal pathological changes in the lung, is caused by
aberrant wound healing, deposition of extracellular matrix (ECM), and eventually …