The growing preference for producing cytochrome P450-mediated natural products in
microbial systems stems from the challenging nature of the organic chemistry approaches …

Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …

Amine transaminases constitute an important class of enzymes for the synthesis of chiral
amines, which are commonly used as building blocks in pharmaceutical compounds and …

Abstract Cytochrome P450 monooxygenases (CYPs/P450s) are heme-thiolate proteins with
broad chemical functionality that have widespread application as powerful biocatalysts …

C− H oxyfunctionalisation remains a distinct challenge for synthetic organic chemists.
Oxygenases and peroxygenases (grouped here as “oxygenating biocatalysts”) catalyse the …

Among biobased polymers, polylactic acid (PLA) is recognized as one of the most promising
bioplastics to replace petrochemical‐based polymers. PLA is typically blended with other …

Protein engineering campaigns are driven by the demand for superior enzyme performance
under non-natural process conditions, such as elevated temperature or non-neutral pH, to …

Cytochrome P450s (CYPs) are heme‐thiolated enzymes that catalyze the oxidation of C‐H
bonds in a regio‐and stereo‐selective manner. CYPs are widely present in the biological …

Saturation mutagenesis at seven first-sphere residues of the cytochrome P450
monooxygenase 154E1 (CYP154E1) from Thermobifida fusca YX was applied to construct a …

Biocatalysis is considered a green and environmentally friendly technology. Therefore,
novel enzymes and enzymatic systems, together with cascades and protein engineering …