A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Caspases in cell death, inflammation, and disease
N Van Opdenbosch, M Lamkanfi - Immunity, 2019 - cell.com
Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …
involved in cell death and inflammation responses. A wealth of foundational insight into the …
Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
The immunology of macrophage activation syndrome
CB Crayne, S Albeituni, KE Nichols… - Frontiers in …, 2019 - frontiersin.org
Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …
Pediatric hemophagocytic lymphohistiocytosis
SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
Overview of the IL‐1 family in innate inflammation and acquired immunity
CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
Abstract The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11;
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …