Inflammatory bowel disease (IBD), as a representative inflammatory disease, currently has
multiple effective treatment options available and new therapeutic strategies are being …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Background The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE)
initiative of the International Organization for the Study of Inflammatory Bowel Diseases …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

The current coronavirus pandemic is an ongoing global health crisis due to COVID-19,
caused by severe acute respiratory syndrome coronavirus 2. Although COVID-19 leads to …

The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …

Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract
and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative …

Various therapeutic advances have led to a paradigm shift in the clinical management of
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …

Background & Aims We evaluated the efficacy and safety of upadacitinib, an oral selective
Janus kinase 1 inhibitor, in a randomized trial of patients with Crohn's disease (CD) …

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of
molecules associated with one of the major pathways through which many cytokines exert …