There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM),
and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many …

Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway that eliminates
substrate proteins through heat‐shock cognate protein 70 recognition and lysosome …

Background Autophagic flux is coordinated by a network of master regulatory genes, which
centered on transcription factor EB (TFEB). The disorders of autophagic flux are closely …

Background Alzheimer's disease (AD) is a complicated and refractory neurodegenerative
disease that is typically characterized by memory loss and multiple cognitive impairments …

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment that increasingly affects the elderly. AD's main features have been related to …

Abstract Background In recent years, Salvia miltiorrhiza and its active substances have
remarkably progressed in treating central neurological disorders. Tanshinone IIA (TSA) is an …

Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …

The highly complex pathophysiology of Alzheimer's disease (AD) and the low bioavailability
of the currently used drugs make it necessary to offer versatile treatment options. In this …

Imidacloprid (IMI) insecticide is rapidly metabolized in mammals and contributes to
neurotoxicity via the blocking of nicotinic acetylcholine receptors, as in insects. Origanum …

Extracellular clustering of amyloid-β (Aβ) and an impaired autophagy lysosomal pathway
(ALP) are the hallmark features in the early stages of incurable Alzheimer's disease (AD) …