Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Increased plasma homocysteine is a risk factor for several pathological disorders. The
present review focused on the role of homocysteine (Hcy) in different population groups …

Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …

A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …

Members of the serum paraoxonase (PON) family have been identified in mammals and
other vertebrates, and in invertebrates. PONs exhibit a wide range of physiologically …

During atherogenesis, antioxidants prevent the formation of oxidized LDL1. It has been
reported that serum paraoxonase (PON) activity is correlated to severity of the coronary …

Abstract Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma
high-density lipoprotein (HDL), was the first member of this family of enzymes to be …

N‐acylhomoserine lactones (AHLs) are used as signal molecules by many quorum‐sensing
Proteobacteria. Diverse plant and animal pathogens use AHLs to regulate infection and …

The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and
PON3, aligned next to each other on chromosome 7. By far the most-studied member of the …