Current scenario of pyrazole hybrids with in vivo therapeutic potential against cancers

Z Xu, Y Zhuang, Q Chen - European Journal of Medicinal Chemistry, 2023 - Elsevier
Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

Electrosynthesis of Highly Functionalized Polycyclic N-Heteroaromatics through Cascade Radical Cyclization and Alkoxylation in Batch and Continuous-Flow

J Chen, Y Qiao, W Guan, C Yuan, Y Yao… - ACS Sustainable …, 2023 - ACS Publications
Electrochemical radical cascade cyclization has been recognized as a powerful,
straightforward, and environmentally-friendly synthetic tool to give highly functionalized …

Synthesis, Characterization, Antioxidant, and Anticancer Activity against Colon Cancer Cells of Some Cinnamaldehyde-Based Chalcone Derivatives

MA El-Atawy, DH Hanna, AH Bashal, HA Ahmed… - Biomolecules, 2024 - mdpi.com
The purpose of the current investigation was to produce cinammaldehyde-based chalcone
derivatives (3a–k) to evaluate their potential effectiveness as antioxidant and inhibitory …

CuI-catalyzed synthesis of multisubstituted pyrido [1, 2-a] pyrimidin-4-ones through tandem Ullmann-type C–N cross-coupling and intramolecular amidation reaction

B Mo, C Chen, J Peng - RSC advances, 2023 - pubs.rsc.org
Various multi-substituted pyrido [1, 2-a] pyrimidin-4-ones were synthesized via a one-pot
tandem CuI-catalyzed C–N bond formation/intramolecular amidation reaction at 130° C in …

Structural Modification Strategies of Triazoles in Anticancer Drug Development

Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …

[HTML][HTML] Advances in synthesis, medicinal properties and biomedical applications of Pyridine Derivatives: A Comprehensive Review

D Sahu, PSR Sreekanth, PK Behera… - European Journal of …, 2024 - Elsevier
Pyridine derivatives have emerged as promising candidates in the field of biomedical
research, showcasing a wide array of applications in drug development and therapeutic …

Efficient synthesis and evaluation of novel 6-arylamino-[1, 2, 4] triazolo [4, 3-a] pyridine derivatives as antiproliferative agents

MY Lin, TY Ji, M Zheng, YY Chen, SY Xu… - Bioorganic & Medicinal …, 2022 - Elsevier
Based on our previous work, a series of novel 6-arylamino-[1, 2, 4] triazolo [4, 3-a] pyridine
derivatives were synthesized, and evaluated for antiproliferative activities. SAR studies …

Regioselective Synthesis of Cycloalkane-fused Pyrazolo [4, 3-e] pyridines through Tandem Reaction of 5-aminopyrazoles, Cyclic Ketones and Electron-rich Olefins

P Cuervo-Prado, F Orozco-López… - Current Organic …, 2024 - ingentaconnect.com
Background: Pyrazolopyridines are interesting fused heterocyclic pharmacophores that
combine pyrazole and pyridine; two privileged nuclei extensively studied and with a wide …

Synthesis of 1-Amino-3-oxo-2,7-naphthyridines via Smiles Rearrangement: A New Approach in the Field of Chemistry of Heterocyclic Compounds

SN Sirakanyan, D Spinelli, A Geronikaki… - International Journal of …, 2022 - mdpi.com
In this paper we describe an efficient method for the synthesis of new heterocyclic systems:
furo [2, 3-c]-2, 7-naphthyridines 6, as well as a new method for the preparation of 1, 3 …