Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

The biological characteristics of the tumour are used to estimate prognosis and select
appropriate systemic therapy for patients with (breast) cancer. The advent of molecular …

Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we …

Vascular endothelial cell growth factor, a mitogen selective for vascular endothelial cells in
vitro that promotes angiogenesis in vivo, functions through distinct membrane-spanning …

Background: Axillary lymph node status has been the most important prognostic factor in
operable breast carcinoma, but it does not fully account for the varied disease outcome …

Tumor growth and metastasis require angiogenesis; and microvessel density, a measure of
tumor angiogenesis, correlates with metastasis in breast and lung carcinoma. To determine …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator composed of HIF-1α and HIF-
1β subunits. Several dozen HIF-1 targets are known, including the gene encoding vascular …

Abundant evidence has shown that tumor growth and metastasis are dependent upon tumor
angiogenesis (TA). TA refers to the growth of new vessels toward and within the tumor. Until …

FGF-2 and VEGF are potent angiogenesis inducers in vivo and in vitro. Here we show that
FGF-2 induces VEGF expression in vascular endothelial cells through autocrine and …

In this issue, Hollingsworth et a1l present evidence that increasing intratumor microvessel
density in the areas of most intense neovascularization is associated with decreasing overall …