Single-cell transcriptomics has recently emerged as a powerful tool to analyze cellular
heterogeneity, discover new cell types, and infer putative differentiation routes. The …

PU. 1 is an ETS-family transcription factor that plays a broad range of roles in
hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …

Despite great advances in understanding the mechanisms underlying blood production,
lineage specification at the level of multipotent progenitors (MPPs) remains poorly …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

Regulated blood production is achieved through the hierarchical organization of dormant
hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division …

Hematopoietic stem cells (HSCs) sustain blood formation throughout life and are the
functional units of bone marrow transplantation. We show that transient expression of six …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …

Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …