Monocytes in the tumor microenvironment
S Ugel, S Canè, F De Sanctis… - Annual Review of …, 2021 - annualreviews.org
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
Monocyte heterogeneity and functions in cancer
Monocytes are innate immune cells of the mononuclear phagocyte system that have
emerged as important regulators of cancer development and progression. Our …
emerged as important regulators of cancer development and progression. Our …
[HTML][HTML] Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy
Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in
hepatocellular carcinoma (HCC) and other cancers, mediated in part by the …
hepatocellular carcinoma (HCC) and other cancers, mediated in part by the …
A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors
Clinical immunotherapy of solid tumors elicits durable responses only in a minority of
patients, largely due to the highly immunosuppressive tumor microenvironment (TME) …
patients, largely due to the highly immunosuppressive tumor microenvironment (TME) …
[HTML][HTML] Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
Activation of unfolded protein responses (UPRs) in cancer cells undergoing endoplasmic
reticulum (ER) stress promotes survival. However, how UPR in tumor cells impacts anti …
reticulum (ER) stress promotes survival. However, how UPR in tumor cells impacts anti …
p53 at the crossroads of tumor immunity
G Efe, AK Rustgi, C Prives - Nature Cancer, 2024 - nature.com
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and
consequences that impact diverse cell types and tissues. Recent studies are beginning to …
consequences that impact diverse cell types and tissues. Recent studies are beginning to …
Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways
Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …
p53, cancer and the immune response
J Blagih, MD Buck, KH Vousden - Journal of cell science, 2020 - journals.biologists.com
The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …
The ontogeny of monocyte subsets
AA Wolf, A Yáñez, PK Barman… - Frontiers in …, 2019 - frontiersin.org
Classical and non-classical monocytes, and the macrophages and monocyte-derived
dendritic cells they produce, play key roles in host defense against pathogens, immune …
dendritic cells they produce, play key roles in host defense against pathogens, immune …