The term “cancer stem cell”(CSC) refers to a cancer cell with the following features:
clonogenic ability, the expression of stem cell markers, differentiation into cells of different …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3
inflammasome, however, it remains unclear how crystals induce cell death. Here we report …

Increasing evidence has demonstrated the bidirectional link between acute kidney injury
(AKI) and chronic kidney disease (CKD) such that, in the clinical setting, the new concept of …

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting
in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis …