Automation in the life science research laboratory

I Holland, JA Davies - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Protocols in the academic life science laboratory are heavily reliant on the manual
manipulation of tools, reagents and instruments by a host of research staff and students. In …

Nobel Turing Challenge: creating the engine for scientific discovery

H Kitano - NPJ systems biology and applications, 2021 - nature.com
Scientific discovery has long been one of the central driving forces in our civilization. It
uncovered the principles of the world we live in, and enabled us to invent new technologies …

Elevating chemistry research with a modern electronics toolkit

GRD Prabhu, PL Urban - Chemical Reviews, 2020 - ACS Publications
With the rapid development of high technology, chemical science is not as it used to be a
century ago. Many chemists acquire and utilize skills that are well beyond the traditional …

The impact of FGFR3 alterations on the tumor microenvironment and the efficacy of immune checkpoint inhibitors in bladder cancer

K Komura, K Hirosuna, S Tokushige, T Tsujino… - Molecular Cancer, 2023 - Springer
Background Currently, only limited knowledge is available regarding the phenotypic
association between fibroblast growth factor receptor 3 (FGFR3) alterations and the tumor …

Towards a modular architecture for science factories

R Vescovi, T Ginsburg, K Hippe, D Ozgulbas… - Digital …, 2023 - pubs.rsc.org
Advances in robotic automation, high-performance computing (HPC), and artificial
intelligence (AI) encourage us to conceive of science factories: large, general-purpose …

Robotic search for optimal cell culture in regenerative medicine

GN Kanda, T Tsuzuki, M Terada, N Sakai, N Motozawa… - Elife, 2022 - elifesciences.org
Induced differentiation is one of the most experience-and skill-dependent experimental
processes in regenerative medicine, and establishing optimal conditions often takes years …

A new era for space life science: international standards for space omics processing

L Rutter, R Barker, D Bezdan, H Cope, SV Costes… - Patterns, 2020 - cell.com
Space agencies have announced plans for human missions to the Moon to prepare for
Mars. However, the space environment presents stressors that include radiation …

Core processes in intelligent robotic lab assistants: Flexible liquid handling

D Knobbe, H Zwirnmann, M Eckhoff… - 2022 IEEE/RSJ …, 2022 - ieeexplore.ieee.org
Laboratory automation is a suitable solution to establish higher reproducibility with less
manual work and thus higher quality standards in life sciences. To date, mobile robots are …

Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation

M Kubo, T Nishiyama, Y Tamada, R Sano… - Nucleic Acids …, 2019 - academic.oup.com
Next-generation sequencing technologies have made it possible to carry out transcriptome
analysis at the single-cell level. Single-cell RNA-sequencing (scRNA-seq) data provide …

A variable scheduling maintenance culture platform for mammalian cells

K Ochiai, N Motozawa, M Terada… - SLAS …, 2021 - journals.sagepub.com
Cell culturing is a basic experimental technique in cell biology and medical science.
However, culturing high-quality cells with a high degree of reproducibility relies heavily on …