Of mice and men: bridging the translational disconnect in CNS drug discovery
H Geerts - CNS drugs, 2009 - Springer
The tremendous advances in transgene animal technology, especially in the area of
Alzheimer's disease, have not resulted in a significantly better success rate for drugs …
Alzheimer's disease, have not resulted in a significantly better success rate for drugs …
Degeneracy as a substrate for respiratory regulation
NM Mellen - Respiratory physiology & neurobiology, 2010 - Elsevier
Recent studies in vivo and in vitro suggest that both respiratory rhythmogenesis and its
central chemosensory modulation arise from multiple, mechanistically and/or anatomically …
central chemosensory modulation arise from multiple, mechanistically and/or anatomically …
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
Tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) is an endogenous
secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells …
secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells …
Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis
E Michael, BK Singh - BMC medicine, 2016 - Springer
Background The current WHO-led initiative to eradicate the macroparasitic disease,
lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) …
lymphatic filariasis (LF), based on single-dose annual mass drug administration (MDA) …
Ensembles of uncertain mathematical models can identify network response to therapeutic interventions
D Luan, F Szlam, KA Tanaka, PS Barie… - Molecular …, 2010 - pubs.rsc.org
The role of mechanistic modeling and systems biology in molecular medicine remains
unclear. In this study, we explored whether uncertain models could be used to understand …
unclear. In this study, we explored whether uncertain models could be used to understand …
Modeling and analysis of the molecular basis of pain in sensory neurons
SO Song, J Varner - PLoS One, 2009 - journals.plos.org
Intracellular calcium dynamics are critical to cellular functions like pain transmission.
Extracellular ATP plays an important role in modulating intracellular calcium levels by …
Extracellular ATP plays an important role in modulating intracellular calcium levels by …
Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems
Androgen ablation therapy is currently the primary treatment for metastatic prostate cancer.
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer …
Unfortunately, in nearly all cases, androgen ablation fails to permanently arrest cancer …
Reduced order modeling and analysis of the human complement system
Complement is an important pathway in innate immunity, inflammation, and many disease
processes. However, despite its importance, there are few validated mathematical models of …
processes. However, despite its importance, there are few validated mathematical models of …
Modelling and analysis of an ensemble of eukaryotic translation initiation models
Programmed protein synthesis plays an important role in the cell cycle. Deregulated
translation has been observed in several cancers. In this study, the authors constructed an …
translation has been observed in several cancers. In this study, the authors constructed an …
Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells
Manipulation of differentiation programs has therapeutic potential in a spectrum of human
cancers and neurodegenerative disorders. In this study, we integrated computational and …
cancers and neurodegenerative disorders. In this study, we integrated computational and …