Abstract γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the
mammalian brain and has been found to play an important role in the pathogenesis or the …

CDKL5 deficiency disorder (CDD) is a developmental and epileptic encephalopathy (DEE)
characterized by severe early-onset intractable epilepsy and motor, cognitive, visual, and …

Background and Objective CDKL5 deficiency disorder presents as a challenging condition
with early-onset refractory seizures, severe developmental delays, and a range of other …

Aim To describe the experiences and unmet medical care needs of a group of parents of
children with developmental and epileptic encephalopathies (DEEs) caused by the SCN1A …

CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by
global developmental delay, early-onset seizures, intellectual disability, visual and motor …

Objective The study was conducted to analyze the possible diagnostic value of the
electroclinical semiology of the epileptic seizures. Methods We evaluated the medical …

ABSTRACT Introduction Developmental and Epileptic Encephalopathies (DEEs)
encompass a group of neurological disorders caused by either abnormal neuronal …

Gastrointestinal symptoms are common in most forms of neurodevelopment disorders
(NDDs) such as in autism spectrum disorders (ASD). The current patient-reported outcome …

Aim To compare growth in individuals with cyclin‐dependent kinase‐like 5 (CDKL5)
deficiency disorder with population norms and to investigate the effect of gastrostomy on …

Safety and Efficacy of Ganaxolone in Patients With CDKL5 Deficiency Disorder: Results
From the Double-Blind Phase of a Randomised, Placebo-Controlled, Phase 3 Trial Knight …