The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Fast volumetric imaging is essential for understanding the function of excitable tissues such
as those found in the brain and heart. Measuring cardiac voltage transients in tissue …

In the adult heart, acute adaptation of electrical and mechanical activity to changes in
mechanical load occurs via feedback processes known as “mechano-electric coupling” and …

The atrioventricular canal (AVC) is the site where key structures responsible for functional
division between heart regions are established, most importantly, the atrioventricular (AV) …

Cardiac excitation originates in the sinoatrial node (SAN), due to the automaticity of this
distinct region of the heart. SAN automaticity is the result of a gradual depolarisation of the …

Optogenetics, involving the optical measurement and manipulation of cellular activity with
genetically encoded light-sensitive proteins (“reporters” and “actuators”), is a powerful …

Popeye domain-containing (POPDC) proteins selectively bind cAMP and mediate cellular
responses to sympathetic nervous system (SNS) stimulation. The first discovered human …

The heart is a complex multicellular organ comprising both cardiomyocytes (CM), which
make up the majority of the cardiac volume, and non-myocytes (NM), which represent the …

The HCN4 channel is essential for heart rate regulation in vertebrates by generating
pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause …