The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …

Although microglial activation is associated with all CNS disorders, many of which are
sexually dimorphic or age‐dependent, little is known about whether microglial basal gene …

Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and
humanistic burden. Currently available treatment strategies mostly rely on antipsychotic …

Recent results from laboratory investigations and clinical trials indicate important roles for
estrogen receptor (ER) agonists in protecting the central nervous system (CNS) from …

Myelin is an essential structure that protects axons, provides metabolic support to neurons
and allows fast nerve transmission. Several neurological diseases, such as multiple …

Microglial cells are the primary mediators of the CNS immune defense system and crucial for
shaping inflammatory responses. They represent a highly dynamic cell population which is …