The role of inflammation in the initiation and progression of myeloid neoplasms
Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …
Inflammation is emerging as a novel driver of myeloid malignancy, with important …
Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer
RNA-binding proteins (RBPs) play an important role in RNA metabolism, regulating the
stability, localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network …
stability, localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network …
[HTML][HTML] Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
A central goal of genetics is to define the relationships between genotypes and phenotypes.
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single …
High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single …
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses
ME Cook, TR Bradstreet, AM Webber, J Kim… - Science …, 2022 - science.org
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine
production. The zinc finger protein 36 (ZFP36) family genes (Zfp36, Zfp36l1, and Zfp36l2) …
production. The zinc finger protein 36 (ZFP36) family genes (Zfp36, Zfp36l1, and Zfp36l2) …
Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq
Pooled CRISPR screens coupled with single-cell RNA-sequencing have enabled systematic
interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA …
interrogation of gene function and regulatory networks. Here, we introduce Cas13 RNA …
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis
H Zhu, K Chen, Y Chen, J Liu, X Zhang… - Signal transduction and …, 2022 - nature.com
RNA-binding proteins (RBPs) play important roles in cancer development and treatment.
However, the tumor-promoting RBPs and their partners, which may potentially serve as the …
However, the tumor-promoting RBPs and their partners, which may potentially serve as the …
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
B cell progenitor acute lymphoblastic leukemia (B-ALL) treatment has been revolutionized
by T cell-based immunotherapies—including chimeric antigen receptor T cell therapy (CAR …
by T cell-based immunotherapies—including chimeric antigen receptor T cell therapy (CAR …
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models
V Rondeau, JM Berman, T Ling, C O'Brien… - Science translational …, 2024 - science.org
Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare
subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease …
subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease …
A single‐cell transcriptomic atlas characterizes age‐related changes of murine cranial stem cell niches
The craniofacial bones provide structural support for the skull and accommodate the
vulnerable brain tissue with a protective cavity. The bone tissue undergoes constant …
vulnerable brain tissue with a protective cavity. The bone tissue undergoes constant …
Massively Parallel CRISPR‐Based Genetic Perturbation Screening at Single‐Cell Resolution
J Cheng, G Lin, T Wang, Y Wang, W Guo… - Advanced …, 2023 - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR)‐based genetic
screening has been demonstrated as a powerful approach for unbiased functional genomics …
screening has been demonstrated as a powerful approach for unbiased functional genomics …