Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells
J Louradour, O Bortolotti, E Torre, I Bidaud, N Lamb… - Cells, 2022 - mdpi.com
Background: Sinoatrial node cells (SANC) automaticity is generated by functional
association between the activity of plasmalemmal ion channels and local diastolic …
association between the activity of plasmalemmal ion channels and local diastolic …
The organization of the sinoatrial node microvasculature varies regionally to match local myocyte excitability
The cardiac cycle starts when an action potential is produced by pacemaking cells in the
sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million …
sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million …
Paradigm shift: new concepts for HCN4 function in cardiac pacemaking
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …
correlate of the If current and are critically involved in controlling neuronal excitability and …
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling
L Guarina, AN Moghbel… - Journal of General …, 2022 - rupress.org
Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …
Principles, mechanisms and functions of entrainment in biological oscillators
A Jiménez, Y Lu, A Jambhekar… - Interface Focus, 2022 - royalsocietypublishing.org
Entrainment is a phenomenon in which two oscillators interact with each other, typically
through physical or chemical means, to synchronize their oscillations. This phenomenon …
through physical or chemical means, to synchronize their oscillations. This phenomenon …
In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability
K Hennis, RD Rötzer, J Rilling, Y Wu… - Nature …, 2022 - nature.com
The mouse is a common and cost-effective animal model for basic research, and the number
of genetically engineered mouse models with cardiac phenotype is increasing. In vivo …
of genetically engineered mouse models with cardiac phenotype is increasing. In vivo …
[HTML][HTML] Beyond pacemaking: HCN channels in sinoatrial node function
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key proteins
involved in the initiation and regulation of the heartbeat. Pacemaker cells within the …
involved in the initiation and regulation of the heartbeat. Pacemaker cells within the …
Genetics of sinoatrial node function and heart rate disorders
LE van der Maarel, AV Postma… - Disease models & …, 2023 - journals.biologists.com
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …
electrical activation and ensuring that the heart's functional cardiac output meets …