Diet has a pivotal role in shaping the composition, function and diversity of the gut
microbiome, with various diets having a profound impact on the stability, functionality and …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. HD
patients present with movement disorders, behavioral and psychiatric symptoms and …

The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the
minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …

Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease
(AD), but vascular–tau associations and their effects on cognition are poorly understood. We …

The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …