Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …

Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial
cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's …