Behavioral and pharmacological responses of selectively bred and inbred rodent lines have
been analyzed to elucidate many features of drug sensitivity and the adverse effects of …

▪ Abstract Even the most extreme environmentalists along the nature-nurture continuum in
psychology now acknowledge that genes often contribute to individual differences in …

Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal
(physiological dependence), or compulsive behavior related to alcohol use. Studies of strain …

The primary concerns for providing anesthesia to the patient with epilepsy are the capacity
of anesthetics to modulate or potentiate seizure activity and the interaction of anesthetic …

Here, we map a quantitative trait locus (QTL) with a large effect on predisposition to
barbiturate (pentobarbital) withdrawal to a 0.44 Mb interval of mouse chromosome 1 …

Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WAS) mice were
genetically selected to express severe or mild handling-induced convulsions(HIC) …

BACKGROUND: Nitrous oxide (N 2 O) is one of the oldest analgesics/adjuvant agents still in
use today; however, its effects on the human electroencephalogram (EEG) remain unclear. It …

Many investigations of alcohol (ethanol) sensitivity have addressed the question of genetic
determination using genetically defined animal populations, particularly mouse and rat …

Recombinant inbred (RI) mouse strains were developed primarily as a tool to detect and
provisionally map major gene loci—those with effects large enough to cause a bimodal …

Several methods have been applied to the study of the genetic determinants of ethanol
(EtOH) sensitivity in animals. The use of inbred strains has indicated that virtually all …