The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix
ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ heterodimers …

During angiogenesis, αv integrins are overexpressed on the endothelial cell surface to
facilitate the growth and survival of newly forming vessels. Accordingly, blocking αv integrin …

Multicellular organisms must coordinate signals from adhesion receptors with those from
other signalling receptors (for example, growth factor receptors). Here, we briefly review …

Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP)
activity critical for extracellular matrix turnover associated with both physiologic and …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

Pharmacological agents directed against the integrins αvβ3 and αvβ5 have been reported to
inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail …

Purpose To determine the molecular basis of corneal avascularity during wound healing
and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis …

The integrin receptor αvβ3 has been shown to play a critical role in several distinct
processes, such as angiogenesis, osteoclast-mediated bone resorption and tumor …

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes
to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins …

Corneal avascularity is necessary for the preservation of optimal vision. The cornea
maintains a dynamic balance between pro-and antiangiogenic factors that allows it to …