Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Perianal fistulizing Crohn's disease has a major negative effect on patient quality of life and
is a predictor of poor long-term outcomes. Factors involved in the pathogenesis of perianal …

Background and Aims Causes of inflammatory bowel diseases are not well understood and
the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes …

Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …

Inflammatory bowel disease (IBD), historically subdivided into Crohn's disease and
ulcerative colitis, is a very heterogeneous condition. While the tendency in medicine is to try …

Perianal fistulizing Crohn's disease (CD) represents a severe phenotype of CD that is
associated with significant morbidity and reduction in quality of life. Perianal fistulizing CD is …

Abstract Background and Aims Perianal lesion is a refractory phenotype of Crohn's disease
[CD] with significantly diminished quality of life. We evaluated the clinical characteristics of …

Background Perianal complications in patients with Crohn's disease are common and have
a negative impact on the patients' quality of life. Data about the long-term disease course of …

Perianal fistulizing Crohn's Disease (pCD) affects about 25% of patients with Crohn's
Disease (CD). It remains a difficult entity to manage with a therapeutic ceiling of treatment …

Objective Perianal Crohn's disease (pCD) occurs in up to 40% of patients with CD and is
associated with poor quality of life, limited treatment responses and poorly understood …