Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

Oesophageal cancer is the sixth most common cause of cancer-related death worldwide
and is therefore a major global health challenge. The two major subtypes of oesophageal …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has
long been anticipated that our understanding of the basic principles of cell cycle control …

Inhibitors of cyclin-dependent kinases (CDKs) 4/6 have emerged as a powerful class of
agents with clinical activity in several malignancies. Targeting the cell cycle represents a …

Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising
incidence. Understanding of the genetic events driving EAC development is limited, and …

Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle
regulation would contribute to promising cancer therapies. In particular, cyclin-dependent …

A more detailed understanding of the somatic genetic events that drive gastrointestinal
adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high …

Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …

The dysregulation of Fbxo4-cyclin D1 axis occurs at high frequency in esophageal
squamous cell carcinoma (ESCC), where it promotes ESCC development and progression …