Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

1. Introduction Allergic rhinitis (AR) is a high-prevalence disease in many developed
countries, affecting about 10±20% of the general population (1±5). Several studies based on …

The H1-receptor antagonists are among the most widely used medications in the world. We
review here the molecular basis of their action and their clinical pharmacology, efficacy in …

Synopsis Cetirizine, the carboxylated metabolite of hydroxyzine, is a specific and long-acting
histamine H 1-receptor antagonist. It has marked antiallergic properties and inhibits …

Background: Fexofenadine hydrochloride (HCl) is a new H 1 antihistamine used twice daily
in some countries. Objective: A multicenter, double-blind, parallel-group, placebo-controlled …

First-generation histamine H 1-receptor antagonists, such as diphenhydramine, triprolidine,
hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other …

Cetirizine is a selective, second-generation histamine H 1 receptor antagonist, with a rapid
onset, a long duration of activity and low potential for interaction with drugs metabolised by …

The incidence of obesity in the United States has reached epidemic proportions. Previous
research has shown several medications exert noticeable effects on body‐weight regulation …

BACKGROUND: Cetirizine, a new once-daily highly specific H1-antagonist, has been shown
in conventional studies to be efficacious in the treatment of seasonal and perennial allergic …