Malaria chemoprevention and drug resistance: a review of the literature and policy implications
CV Plowe - Malaria Journal, 2022 - Springer
Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …
Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana
ST Girgis, E Adika, FE Nenyewodey… - Nature …, 2023 - nature.com
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …
children living in sub-Saharan Africa. Molecular surveillance can provide important …
Prevalence of mutations associated with artemisinin partial resistance and sulfadoxine–pyrimethamine resistance in 13 regions in Tanzania in 2021: a cross-sectional …
Background The emergence of the artemisinin partial resistance (ART-R) mutation in the
Plasmodium falciparum kelch13 gene (k13), Arg561His, in Rwanda and the regional …
Plasmodium falciparum kelch13 gene (k13), Arg561His, in Rwanda and the regional …
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
Abstract The Democratic Republic of the Congo (DRC) harbors 11% of global malaria
cases, yet little is known about the spatial and genetic structure of the parasite population in …
cases, yet little is known about the spatial and genetic structure of the parasite population in …
[HTML][HTML] Country wide surveillance reveals prevalent artemisinin partial resistance mutations with evidence for multiple origins and expansion of high level sulfadoxine …
Background: Emergence of artemisinin partial resistance (ART-R) in Plasmodium falciparum
is a growing threat to the efficacy of artemisinin combination therapies (ACT) and the efforts …
is a growing threat to the efficacy of artemisinin combination therapies (ACT) and the efforts …
Describing the current status of Plasmodium falciparum population structure and drug resistance within mainland Tanzania using molecular inversion probes
High‐throughput Plasmodium genomic data is increasingly useful in assessing prevalence
of clinically important mutations and malaria transmission patterns. Understanding parasite …
of clinically important mutations and malaria transmission patterns. Understanding parasite …
Potential opportunities and challenges of deploying next generation sequencing and CRISPR-Cas systems to support diagnostics and surveillance towards malaria …
Recent developments in molecular biology and genomics have revolutionized biology and
medicine mainly in the developed world. The application of next generation sequencing …
medicine mainly in the developed world. The application of next generation sequencing …
Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago
Abstract Background Tanzania's Zanzibar archipelago has made significant gains in malaria
control over the last decade and is a target for malaria elimination. Despite consistent …
control over the last decade and is a target for malaria elimination. Despite consistent …
Intermittent preventive treatment with Sulfadoxine pyrimethamine for malaria: a global overview and challenges affecting optimal drug uptake in pregnant women
RRD Nana, J Hawadak, LPK Foko… - … and Global Health, 2023 - Taylor & Francis
ABSTRACT Malaria in Pregnancy (MiP) leading to morbidity and mortality is a major public
health problem that poses significant risk to pregnant women and their fetus. To cope with …
health problem that poses significant risk to pregnant women and their fetus. To cope with …