Impact of RNA virus evolution on quasispecies formation and virulence

MB Mandary, M Masomian, CL Poh - International journal of molecular …, 2019 - mdpi.com
RNA viruses are known to replicate by low fidelity polymerases and have high mutation
rates whereby the resulting virus population tends to exist as a distribution of mutants. In this …

Integrating molecular modelling methods to advance influenza A virus drug discovery

H Patel, A Kukol - Drug discovery today, 2021 - Elsevier
Highlights•No new influenza A antivirals have gained global approval for nearly two
decades.•Due to influenza A evolution more antiviral options are needed.•Promising anti …

Host nutritional status affects alphavirus virulence, transmission, and evolution

J Weger-Lucarelli, L Carrau, LI Levi, V Rezelj… - PLoS …, 2019 - journals.plos.org
Malnourishment, specifically overweight/obesity and undernourishment, affects more than
2.5 billion people worldwide, with the number affected ever-increasing. Concurrently …

SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission

N Sapoval, M Mahmoud, MD Jochum, Y Liu… - Genome …, 2021 - genome.cshlp.org
The COVID-19 pandemic has sparked an urgent need to uncover the underlying biology of
this devastating disease. Though RNA viruses mutate more rapidly than DNA viruses, there …

[HTML][HTML] Molecular basis of genetic variation of viruses: Error-prone replication

E Domingo - Virus as Populations, 2020 - ncbi.nlm.nih.gov
Genetic variation is a necessity of all biological systems. Viruses use all known mechanisms
of variation; mutation, several forms of recombination, and segment reassortment in the case …

Evolutionary and temporal dynamics of emerging influenza D virus in Europe (2009–22)

M Gaudino, C Chiapponi, A Moreno, S Zohari… - Virus …, 2022 - academic.oup.com
Influenza D virus (IDV) is an emerging influenza virus that was isolated for the first time in
2011 in the USA from swine with respiratory illness. Since then, IDV has been detected …

[HTML][HTML] Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

A McNee, TRF Smith, B Holzer, B Clark… - The Journal of …, 2020 - journals.aai.org
Abstract mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus
infection. However, questions remain whether small animal models accurately predict …

SARS-CoV-2: lessons from both the history of medicine and from the biological behavior of other well-known viruses

S Fiorino, F Tateo, DD Biase, CG Gallo… - Future …, 2021 - Taylor & Francis
SARS-CoV-2 is the etiological agent of the current pandemic worldwide and its associated
disease COVID-19. In this review, we have analyzed SARS-CoV-2 characteristics and those …

Review of genome sequencing technologies in molecular characterization of influenza A viruses in swine

RP Chauhan, ML Gordon - Journal of Veterinary Diagnostic …, 2022 - journals.sagepub.com
The rapidly evolving antigenic diversity of influenza A virus (IAV) genomes in swine makes it
imperative to detect emerging novel strains and track their circulation. We analyzed in our …

Application of next-generation sequencing to reveal how evolutionary dynamics of viral population shape dengue epidemiology

HY Ko, GM Salem, GJJ Chang, DY Chao - Frontiers in Microbiology, 2020 - frontiersin.org
Dengue viral (DENV) infection results in a wide spectrum of clinical manifestations from
asymptomatic, mild fever to severe hemorrhage diseases upon infection. Severe dengue is …