Genetics and Epigenetics in Obesity: What Do We Know so Far?
M Keller, SIA Svensson, K Rohde-Zimmermann… - Current Obesity …, 2023 - Springer
Abstract Purpose of Review Enormous progress has been made in understanding the
genetic architecture of obesity and the correlation of epigenetic marks with obesity and …
genetic architecture of obesity and the correlation of epigenetic marks with obesity and …
[HTML][HTML] Exercise-regulated lipolysis: Its role and mechanism in health and diseases
JY Zhu, L Guo - Journal of Advanced Research, 2024 - Elsevier
Exercise has received considerable attention because of its importance not just in regulating
physiological function, but also in ameliorating multiple pathological processes. Among …
physiological function, but also in ameliorating multiple pathological processes. Among …
Multi-ancestry polygenic mechanisms of type 2 diabetes
Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …
which the underlying biological mechanisms are not fully understood. In this study, we …
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy
N DeForest, Y Wang, Z Zhu, JS Dron… - Nature …, 2024 - nature.com
Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes,
cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological …
cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological …
A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes
In a patient with permanent neonatal syndromic diabetes clinically similar to cases with
ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of …
ONECUT1 biallelic mutations, we identified a disease-causing deletion located upstream of …
Accounting for genetic effect heterogeneity in fine-mapping and improving power to detect gene-environment interactions with SharePro
Classical gene-by-environment interaction (GxE) analysis can be used to characterize
genetic effect heterogeneity but has a high multiple testing burden in the context of genome …
genetic effect heterogeneity but has a high multiple testing burden in the context of genome …
A bioinformatics toolbox to prioritize causal genetic variants in candidate regions
This review addresses the significant challenge of identifying causal genetic variants within
quantitative trait loci (QTLs) for complex traits and diseases. Despite progress in detecting …
quantitative trait loci (QTLs) for complex traits and diseases. Despite progress in detecting …
Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity
SS Das, SK Das - International Journal of Obesity, 2024 - nature.com
Background Obesity is a common disease with a higher prevalence among African
Americans. Obesity alters cellular function in many tissues, including skeletal muscle, and is …
Americans. Obesity alters cellular function in many tissues, including skeletal muscle, and is …
Dissection of type 2 diabetes: a genetic perspective
Diabetes is a leading cause of global mortality and disability, and its economic burden is
substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all …
substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all …
Multi-omics characterization of type 2 diabetes associated genetic variation
Discerning the mechanisms driving type 2 diabetes (T2D) pathophysiology from genome-
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …