The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Over the past five years, the structures of more than 20 proteins containing coiled-coil
domains have been solved to high resolution. This has provided many new insights into the …

Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-
step transesterification reaction. The catalytic core of these ribozymes is formed by two …

Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-
tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown …

Synthetic oligonucleotide analogs have greatly aided our understanding of several
biochemical processes. Efficient solid-phase and enzyme-assisted synthetic methods and …

The solution structure of a human immunodeficiency virus type-1 (HIV-1) Rev peptide bound
to stem-loop IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic …