Folding and stability of ankyrin repeats control biological protein function

A Kumar, J Balbach - Biomolecules, 2021 - mdpi.com
Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins
are involved in protein-protein interaction in order to activate or suppress biological …

[HTML][HTML] The diversity of ACBD proteins–From lipid binding to protein modulators and organelle tethers

M Islinger, JL Costello, S Kors, E Soupene… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Members of the large multigene family of acyl-CoA binding domain containing proteins
(ACBDs) share a conserved motif required for binding of Coenzyme A esterified fatty acids of …

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

HE Adcox, JR Hunt, PE Allen, TE Siff… - Nature …, 2024 - nature.com
How intracellular bacteria subvert the major histocompatibility complex (MHC) class I
pathway is poorly understood. Here, we show that the obligate intracellular bacterium …

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

DT Patel, PJ Stogios, L Jaroszewski… - Molecular Systems …, 2025 - embopress.org
Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex

J Von Dwingelo, IYW Chung, CT Price, L Li, S Jones… - MBio, 2019 - Am Soc Microbiol
Species of the Legionella genus encode at least 18,000 effector proteins that are
translocated through the Dot/Icm type IVB translocation system into macrophages and protist …

Harnessing transcription factor Mga2 and fatty acid elongases to overproduce palmitoleic acid in Saccharomyces cerevisiae

Y Zhang, J Pang, S Liu, K Nie, L Deng, F Wang… - Biochemical Engineering …, 2022 - Elsevier
As a long chain monounsaturated fatty acid, palmitoleic acid (POA) can be widely applied in
medicine, food and industry. However, the limited natural sources and relatively low content …

Poxviral ANKR/F-box proteins: substrate adapters for ubiquitylation and more

RJ Ingham, F Loubich Facundo, J Dong - Pathogens, 2022 - mdpi.com
Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate
species. The large genomes of poxviruses contain numerous genes that allow these viruses …

Microtubule organelles in Giardia

KD Hagen, SG McInally, ND Hilton, SC Dawson - Advances in parasitology, 2020 - Elsevier
Giardia lamblia is a widespread parasitic protist with a complex MT cytoskeleton that is
critical for motility, attachment, mitosis and cell division, and transitions between its two life …

Vermamoeba vermiformis CDC-19 draft genome sequence reveals considerable gene trafficking including with candidate phyla radiation and giant viruses

N Chelkha, I Hasni, AC Louazani, A Levasseur… - Scientific reports, 2020 - nature.com
Vermamoeba vermiformis is a predominant free-living amoeba in human environments and
amongst the most common amoebae that can cause severe infections in humans. It is a …

Unique ankyrin repeat proteins in the genome of poxviruses-Boon or Wane, a critical review

T Gupta, R Chahota - Gene, 2024 - Elsevier
Ankyrin repeat is a 33-amino acid motif commonly observed in eukaryotes and, to a lesser
extent, in prokaryotes and archaea and rarely in viruses. This motif plays a crucial role in …