Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Recruitment of brown/beige adipocytes (BAs) in white adipose tissue (WAT) involves
proliferation and differentiation of adipocyte stem cells (ASCs) in concert with close …

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In
rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

To fulfill its role as the major energy-storing tissue, adipose has several unique properties
that cannot be seen in any other organ, including an almost unlimited capacity to expand in …

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …