Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

Prevention and treatment of dyslipidemia should be considered as an integral part of
individual cardiovascular prevention interventions, which should be addressed primarily to …

Although mitochondrial disorders are clinically heterogeneous, they frequently involve the
central nervous system and are among the most common neurogenetic disorders …

Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options,
novel therapies are desperately needed. Recent studies have shown that GBM acquires …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be
toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess …

Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological
syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) …

Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells
maintain membrane cholesterol homeostasis is poorly understood. Here, we found that …