Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Biomechanical changes in the heart and vessels drive rapid and dynamic regulation of
blood flow, a vital process for meeting the changing metabolic needs of the peripheral …

Reports of the beneficial roles of butyrate in cardiovascular diseases, such as
atherosclerosis and ischemic stroke, are becoming increasingly abundant. However, the …

Oxidative stress within the vascular endothelium, due to excess generation of reactive
oxygen species (ROS), is thought to be fundamental to the initiation and progression of the …

Type 2 diabetes mellitus (T2DM) is a major health concern which may cause cardiovascular
complications. Insulin resistance (IR), regarded as a hallmark of T2DM, is characterized by …

During recent decades, changes in lifestyle have led to widespread nutritional obesity and
its related complications. Remodelling adipose tissue as a therapeutic goal for obesity and …

Diabetes, a worldwide health concern while burdening significant populace of countries with
time due to a hefty increase in both incidence and prevalence rates. Hyperglycemia has …

Previous studies have shown reduced expression of Src homology 2-containing inositol 5-
phosphatase 2 (SHIP2) and its tumor-suppressive role in gastric cancer (GC). However, the …

Abstract SHIP2 (Src homology 2 domain‐containing inositol 5′‐phosphatase 2) belongs to
the family of 5′‐phosphatases. It regulates the phosphoinositide 3‐kinase (PI3K)‐mediated …

Previous studies found that exposure to polycyclic aromatic hydrocarbons (PAHs) was
associated with type 2 diabetes (T2D) prevalence. However, the potential mechanism is still …