MurG (Rv2153c) is a key player in the biosynthesis of the peptidoglycan layer in
Mycobacterium tuberculosis (Mtb). This work is an attempt to highlight the structural and …

Development of new antimalarial drugs continues to be of huge importance because of the
resistance of malarial parasite towards currently used drugs. Due to the reliance of parasite …

In the present study, we attempted to develop novel class of Mycobacterium tuberculosis
(Mtb) inhibitors by exploring the pharmaceutically underexploited enzyme targets which are …

Mycobacterium tuberculosis glutamate racemase is an essential enzyme involved in
peptidoglycan synthesis and conserved in most bacteria. Small molecule inhibitors were …

Alzheimer's disease (AD) leads to gradual memory loss including other compromised
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …

Pharmacophore approaches are of central contour in drug discovery. However, the
dependence of ligand–based pharmacophore model on appropriate training set molecules …

Background: Tuberculosis is well-known airborne disease caused by Mycobacterium
tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths …

Tuberculosis continues to remain as one of the leading causes of death worldwide, in spite
of significant progress being made in the last twenty years through increased compliance to …

One of the earliest diseases known to afflict humans, tuberculosis (TB), which is brought on
by germs from the Mycobacterium tuberculosis complex, is a leading cause of death …

Background: Tuberculosis (TB) still remains the leading cause of death worldwide and was
unanswered till date. Available treatment strategies have many drawbacks such as longer …