The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
PB Danielson - Current drug metabolism, 2002 - ingentaconnect.com
Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor
J Chen, K Raymond - Annals of clinical microbiology and antimicrobials, 2006 - Springer
Rifampicin, an important drug in the treatment of tuberculosis, is used extensively despite its
broad effects on drug-drug interactions, creating serious problems. The clinical importance …
broad effects on drug-drug interactions, creating serious problems. The clinical importance …
Active transport of imatinib into and out of cells: implications for drug resistance
J Thomas, L Wang, RE Clark, M Pirmohamed - Blood, 2004 - ashpublications.org
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid
leukemia (CML). Not all patients achieve cytogenetic response. Some patients even lose the …
leukemia (CML). Not all patients achieve cytogenetic response. Some patients even lose the …
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
N Chalasani, CJ Gorski, MS Asghar, A Asghar… - Hepatology, 2003 - journals.lww.com
Abstract Cytochrome P450 2E1 (CYP2E1) plays an important role in the pathogenesis of
nonalcoholic steatohepatitis (NASH) in animal models, but its role in the pathogenesis of …
nonalcoholic steatohepatitis (NASH) in animal models, but its role in the pathogenesis of …
Significance of the minor cytochrome P450 3A isoforms
AK Daly - Clinical pharmacokinetics, 2006 - Springer
Abstract Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their …
N Albermann, FH Schmitz-Winnenthal… - Biochemical …, 2005 - Elsevier
ATP binding cassette (ABC)-transporters like P-glycoprotein (multidrug resistance (MDR)
1/ABCB1), the multidrug resistance associated proteins 1 and 2 (MRP1/ABCC1 and …
1/ABCB1), the multidrug resistance associated proteins 1 and 2 (MRP1/ABCC1 and …
Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans
Aims Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has
been implicated in the development of liver disease. Increased hepatic expression of …
been implicated in the development of liver disease. Increased hepatic expression of …
Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?
GT Ho, FM Moodie, J Satsangi - Gut, 2003 - gut.bmj.com
The interface between luminal contents and intestinal epithelium constitutes the largest area
of interaction between the host and the environment. There is now strong evidence that the …
of interaction between the host and the environment. There is now strong evidence that the …
MDR1 genotype-related pharmacokinetics: fact or fiction?
T Sakaeda - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Multidrug resistant transporter MDR1WP-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
From endogenous compounds as biomarkers to plasma‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption …
D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
It is now established that a drug's pharmacokinetics (PK) absorption, distribution,
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …