1. Introduction Administration Heart Failure Trial) and other trials suggest that death is
disproportionately sudden in patients with Over 2 million Americans suffer from heart failure …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

Heart failure (HF) produces important alterations in currents underlying cardiac
repolarization, but the transmural distribution of such changes is unknown. We therefore …

Prolongation of action potential duration is the most consistent electrophysiological
abnormality in myocardium and myocytes from hypertrophied and failing hearts …

A novel in vivo experimental strategy, involving cell type–specific expression of a dominant-
negative K+ channel pore-forming α subunit, was developed and exploited to probe the …

GY Oudit, Z. Kassiri, R. Sah, RJ Ramirez, C. Zobel and PH Backx. The Molecular Physiology
of the Cardiac Transient Outward Potassium Current (Ito) in Normal and Diseased …

Action potential prolongation is a common finding in human heart failure and in animal
models of cardiac hypertrophy. The mechanism of action potential prolongation involves …

Background Cellular electrophysiological alterations may contribute to arrhythmogenesis in
cardiac hypertrophy. An If-like current occurs in left ventricular myocytes (LVMs) isolated …

1 Analyses of whole‐cell voltage‐clamp recordings from isolated adult (C57BL6) mouse
atrial myocytes reveal the presence of two prominent Ca2+‐independent depolarization …

Hypertension-induced cardiac hypertrophy is associated with alterations in ventricular action
potentials. To understand molecular mechanisms underlying this electrical abnormality …