The emerging roles of IFIT3 in antiviral innate immunity and cellular biology

W Zhang, Y Li, S Xin, L Yang, M Jiang… - Journal of medical …, 2023 - Wiley Online Library
The interferon‐inducible protein with tetrapeptide repeats 3 (IFIT3) is one of the most
important members in both the IFIT family and interferon‐stimulated genes family. IFIT3 has …

ISG20: an enigmatic antiviral RNase targeting multiple viruses

S Deymier, C Louvat, F Fiorini, A Cimarelli - FEBS Open Bio, 2022 - Wiley Online Library
Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral
protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase …

HIV triggers a cGAS-dependent, Vpu-and Vpr-regulated type I interferon response in CD4+ T cells

J Vermeire, F Roesch, D Sauter, R Rua, D Hotter… - Cell reports, 2016 - cell.com
Several pattern-recognition receptors sense HIV-1 replication products and induce type I
interferon (IFN-I) production under specific experimental conditions. However, it is thought …

Unbiased Single‐Cell Sequencing of Hematopoietic and Immune Cells from Aplastic Anemia Reveals the Contributors of Hematopoiesis Failure and Dysfunctional …

R Guo, J Kong, P Tang, S Wang, L Sang… - Advanced …, 2024 - Wiley Online Library
Aplastic anemia (AA) is a bone marrow (BM) failure syndrome mediated by hyperactivated T‐
cells with heterogeneous pathogenic factors. The onset of BM failure cannot be accurately …

Comparative transcriptional analysis identified characteristic genes and patterns in HIV-infected immunological non-responders

X Liu, L Lin, L Lu, X Li, Y Han, Z Qiu, X Li, Y Li… - Frontiers in …, 2022 - frontiersin.org
Purpose The incomplete immune reconstitution is a complex phenomenon among human
immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved …

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

H Sertznig, F Roesmann, A Wilhelm… - Frontiers in …, 2022 - frontiersin.org
Efficient HIV-1 replication depends on balanced levels of host cell components including
cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10) …

Influenza A Virus-induced expression of ISG20 inhibits viral replication by interacting with nucleoprotein

H Qu, J Li, L Yang, L Sun, W Liu, H He - Virus genes, 2016 - Springer
Influenza A virus (IAV) is an important pathogen that has a wide range of hosts and
represents a threat to the health of humans and several animal species. IAV infection can …

Virion-associated Vpr alleviates a postintegration block to HIV-1 infection of dendritic cells

CM Miller, H Akiyama, LM Agosto, A Emery… - Journal of …, 2017 - Am Soc Microbiol
Viral protein R (Vpr) is an HIV-1 accessory protein whose function remains poorly
understood. In this report, we sought to determine the requirement of Vpr for facilitating HIV …

Evaluation of the innate immune modulator acitretin as a strategy to clear the HIV reservoir

E Garcia-Vidal, M Castellví, M Pujantell… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The persistence of HIV despite suppressive antiretroviral therapy is a major roadblock to HIV
eradication. Current strategies focused on inducing the expression of latent HIV fail to clear …

Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model

X Chen, B Liao, T Ren, Z Liao, Z Huang, Y Lin, S Zhong… - Heliyon, 2024 - cell.com
Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains
a major public health concern globally. However, administration of inactivated rabies …