Eukaryotic genomes are replicated from large numbers of replication origins distributed on
multiple chromosomes. The activity of these origins must be coordinated so that the entire …

Abstract Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in
eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes …

The imprinted H19 gene has riboregulatory functions. We show here that H19 transcription
is up-regulated during the S-phase of growth-stimulated cells and that the H19 promoter is …

The E2F transcription factor plays a pivotal role in the timely activation of gene expression
during mammalian cell cycle progression, whereas pRB and related proteins control cell …

DNA replication initiation is a complex process involving various genetic and epigenomic
signatures. The correct identification of replication origins (ORIs) could provide important …

Cyclin‐dependent kinases (CDKs) are essential for regulating key transitions in the cell
cycle, including initiation of DNA replication, mitosis and prevention of re‐replication. Here …

Centrosome duplication is a key requirement for bipolar spindle formation and correct
segregation of chromosomes during cell division. In a manner highly reminiscent of DNA …

▪ Abstract The initiation of DNA replication in eukaryotic cells is tightly controlled to ensure
that the genome is faithfully duplicated once each cell cycle. Genetic and biochemical …

Mammalian DNA replication is an elegantly choreographed process in which multiple
components are assembled at the origins to form the prereplication complex. Formation and …

Ever since its discovery, the RB-1 gene and the corresponding protein, pRB, have been a
focal point of cancer research. The isolation of E2F transcription factors provided the key to …