Ribosomal protein S6: a potential therapeutic target against cancer?

YW Yi, KS You, JS Park, SG Lee, YS Seong - International journal of …, 2021 - mdpi.com
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Autophagy and breast cancer: connected in growth, progression, and therapy

Q Wu, D Sharma - Cells, 2023 - mdpi.com
Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota

D Chen, D Jin, S Huang, J Wu, M Xu, T Liu, W Dong… - Cancer letters, 2020 - Elsevier
Gut microbiota dysbiosis is closely involved in intestinal carcinogenesis. A marked reduction
in butyrate-producing bacteria has been observed in patients with colorectal cancer (CRC); …

Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras‐Raf‐MAPK signalling

Y Huang, K Yuan, M Tang, J Yue, L Bao… - Journal of cellular …, 2021 - Wiley Online Library
Melatonin exhibits antitumour activities in the treatment of many human cancers. In the
present study, we aimed to improve the therapeutic potential of melatonin in gastric cancer …

Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

S Gupta, PK Panda, RF Hashimoto, SK Samal… - Scientific Reports, 2022 - nature.com
Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with
DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been …

The multiple roles of autophagy in neural function and diseases

YY Li, ZH Qin, R Sheng - Neuroscience Bulletin, 2024 - Springer
Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …

Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms

S Gupta, DA Silveira, JCM Mombach - DNA repair, 2020 - Elsevier
How a cell determines a given phenotype upon damaged DNA is an open problem. Cell fate
decisions happen at cell cycle checkpoints and it is becoming clearer that the p53 pathway …

[HTML][HTML] The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: a Boolean model of cell death

S Gupta, DA Silveira, JCM Mombach… - Non-coding RNA …, 2023 - Elsevier
Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …

Danlou tablet activates autophagy of vascular adventitial fibroblasts through PI3K/Akt/mTOR to protect cells from damage caused by atherosclerosis

L Wang, T Wu, C Si, H Wang, K Yue, S Shang… - Frontiers in …, 2021 - frontiersin.org
Danlou tablet (DLT), a commercial Chinese patent medicine, has been widely used to treat
cardiovascular diseases for many years. Atherosclerosis (AS) is the leading cause of …

Myocardiocyte autophagy in the context of myocardiocytes regeneration: a potential novel therapeutic strategy

BA Marzoog, TI Vlasova - Egyptian Journal of Medical Human Genetics, 2022 - Springer
Background The regeneration strategy involves several aspects, such as reprogramming
aspects, targeting pathophysiological processes, and inducing the physiological one …