Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

P Dhyani, C Quispe, E Sharma, A Bahukhandi… - Cancer cell …, 2022 - Springer
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases

M Sharifi-Rad, NV Anil Kumar, P Zucca… - Frontiers in …, 2020 - frontiersin.org
Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

J Sharifi-Rad, C Quispe, M Butnariu, LS Rotariu… - Cancer cell …, 2021 - Springer
The study describes the current state of knowledge on nanotechnology and its utilization in
medicine. The focus in this manuscript was on the properties, usage safety, and potentially …

Paclitaxel: application in modern oncology and nanomedicine‐based cancer therapy

J Sharifi-Rad, C Quispe, JK Patra… - Oxidative medicine …, 2021 - Wiley Online Library
Paclitaxel is a broad‐spectrum anticancer compound, which was derived mainly from a
medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a …

Natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms

J Sharifi-Rad, N Cruz-Martins… - Oxidative Medicine …, 2021 - Wiley Online Library
Coumarins belong to the benzopyrone family commonly found in many medicinal plants.
Natural coumarins demonstrated a wide spectrum of pharmacological activities, including …

Diosgenin: an updated pharmacological review and therapeutic perspectives

P Semwal, S Painuli, T Abu-Izneid… - Oxidative medicine …, 2022 - Wiley Online Library
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

ES Ali, K Mitra, S Akter, S Ramproshad, B Mondal… - Cancer cell …, 2022 - Springer
Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …

Emerging potential of 5-Fluorouracil-loaded chitosan nanoparticles in cancer therapy

TT Dongsar, TS Dongsar, N Gupta, WH Almalki… - Journal of Drug Delivery …, 2023 - Elsevier
Cancer is among the leading causes of mortality in the globe. Chemotherapy utilizing
various anticancer medicines continues to be the most widely used form of treatment …

A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer

L Falzone, G Scandurra… - International …, 2021 - spandidos-publications.com
Ovarian cancer represents one of the most aggressive female tumors worldwide. Over the
decades, the therapeutic options for the treatment of ovarian cancer have been improved …