The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology

P Hegyi, OH Petersen - Reviews of Physiology, Biochemistry and …, 2013 - Springer
There are many reviews of pancreatic acinar cell function and also of pancreatic duct
function, but there is an almost total absence of synthetic reviews bringing the integrated …

Microcirculatory derangements in acute pancreatitis

MD Menger, T Plusczyk, B Vollmar - Journal of hepato-biliary-pancreatic …, 2001 - Springer
During the past decade, a considerable number of experimental studies have confirmed the
hypothesis that microcirculatory derangements play a pivotal role in the pathogenesis of …

The acinar cell and early pancreatitis responses

FS Gorelick, E Thrower - Clinical Gastroenterology and Hepatology, 2009 - Elsevier
Pathologic responses arising from the pancreatic acinar cell appear to have a central role in
initiating acute pancreatitis. Environmental factors that sensitize the acinar cell to harmful …

[HTML][HTML] Hyperpolarized magnetic resonance and artificial intelligence: Frontiers of imaging in pancreatic cancer

JS Enriquez, Y Chu, S Pudakalakatti… - JMIR Medical …, 2021 - medinform.jmir.org
Background: There is an unmet need for noninvasive imaging markers that can help identify
the aggressive subtype (s) of pancreatic ductal adenocarcinoma (PDAC) at diagnosis and at …

Emerging therapies to prevent post-ERCP pancreatitis

NR Thiruvengadam, ML Kochman - Current Gastroenterology Reports, 2020 - Springer
Abstract Purpose of Review The aim of this review is to evaluate emerging, novel therapies
for the prevention of post-ERCP pancreatitis. Recent Findings Rectal indomethacin reduces …

Animal models in alcoholic pancreatitis—what can we learn?

A Schneider, DC Whitcomb, MV Singer - Pancreatology, 2002 - Elsevier
Although the majority of patients with chronic pancreatitis present a history of excessive
alcohol consumption, the pathophysiology underlying chronic alcoholic pancreatitis remains …

Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States

F Burton, S Alkaade, D Collins… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 33: 149–159 Summary Background Effectiveness of medical
therapies in chronic pancreatitis has been described in small studies of selected patients …

Pancreatic blood flow with special emphasis on blood perfusion of the islets of Langerhans

L Jansson, PO Carlsson - Comprehensive Physiology, 2011 - Wiley Online Library
The pancreatic islets are more richly vascularized than the exocrine pancreas, and possess
a 5‐to 10‐fold higher basal and stimulated blood flow, which is separately regulated. This is …

[HTML][HTML] Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes

PM Hobbs, WG Johnson… - World Journal of …, 2016 - ncbi.nlm.nih.gov
One of the most challenging issues arising in patients with chronic pancreatitis is the
management of abdominal pain. Many competing theories exist to explain pancreatic pain …

Pathophysiology of chronic pancreatitis

SW Behrman, ES Fowler - Surgical Clinics of North America, 2007 - Elsevier
Although the most common causes of chronic pancreatitis have not changed, it has become
clear that a host of modifying biochemical, inflammatory, neural, and genetic deviations …