Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Cardiomyocyte (CM) replacement is very slow in adult mammalian hearts, preventing
regeneration of damaged myocardium. By contrast, fetal hearts display considerable …

Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …

Direct lineage reprogramming involves the conversion of cellular identity. Single-cell
technologies are useful for deconstructing the considerable heterogeneity that emerges …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-
enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and …

Metastases arise from residual disseminated tumour cells (DTCs). This can happen years
after primary tumour treatment because residual tumour cells can enter dormancy and …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

Abstract RNA-sequencing (RNA-seq) measures the quantitative change in gene expression
over the whole transcriptome, but it lacks spatial context. In contrast, in situ hybridization …